![]() Vogt–Koyanagi–Harada (VKH) disease is a bilateral chronic, diffuse granulomatous panuveitis mediated by an autoimmune attack against pigmented cells by T lymphocytes (Moorthy et al. Retinal transmission function in inactive patients is stronger than that observed in active patients or healthy controls. It is more likely to detect RPE abnormalities with MSI than when using FFA, OCT or FP. Our results show that MSI is a sensitive noninvasive method to investigate the retinal pigment epithelium (RPE) in VKH disease. Additionally, at the same wavelength (590 nm), exposure of choroidal blood vessels in inactive patients was stronger than in healthy controls and active patients (p < 0.01, p < 0.001). Our study showed that MSI detected a higher percentages of these four abnormalities in patients with sunset glow fundus than in patients without this phenomenon (p = 0.0492, p < 0.0001). The percentages of these three abnormalities discovered by MSI in 52 inactive VKH patients with a duration of more than 2 months in VKH were 67.3%, 75% and 84.6% respectively, which were all significantly higher than those detected by FFA, OCT or FP (p = 0.0398, p < 0.0001). ResultsĪ number of features could be recognized by MSI which included (i) general depigmentation, (ii) clumping of pigment and (iii) macular depigmentation and/or hyperpigmentation. Additionally, we compared extent of exposure of choroidal blood vessels between patients with VKH and healthy controls to evaluate retinal transmission function. ![]() The MSI findings were evaluated in combination with fundus fluorescein angiography (FFA), optical coherent tomography (OCT) and fundus photography (FP). ![]() MethodsĪ total of 77 patients with VKH and 163 healthy controls were enrolled between January and April 2015. To investigate fundus abnormalities in Vogt–Koyanagi–Harada (VKH) disease by a noninvasive tool, multispectral imaging (MSI).
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